中文

Principal Investigator

Experiences：

> Director (November 2015-2022), Division of Medical Oncology, Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan

> Assistant Professor (2007-2010), Associate Professor (2010-2013), Professor (2013-2016), Acting Director (2017-2018), Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan

>  Attending Physician (September 2002-March 2015), Director (March 2015-November 2015), Division of Hematology-Oncology, Taipei Veterans General Hospital, Taipei, Taiwan

>  Resident (1996-1999), Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan

>  Chief Resident/Clinical Fellow (1999-2002), Division of Hematology-Oncology, Taipei Veterans General Hospital, Taipei, Taiwan

Education：

• Ph.D., Institute of Clinical Medicine; National Yang-Ming University, Taipei, Taiwan, 2006
• M.D., Faculty of Medicine; National Yang-Ming University, Taipei, Taiwan, 1994

Research areas：

Cancer Biology, Medical Oncology, Hematology, Internal medicine, Head and Neck cancer

Publications：

1. Chang YW, Hsiao HW, Chen JP, Tzeng SF, Tsai CH, Wu CY, Hsieh HH, Carmona SJ, Andreatta M, Di Conza G, Su MT, Koni PA, Ho PC, Chen HK, Yang MH*. A CSF-1R-blocking antibody/IL-10 fusion protein increases anti-tumor immunity by effectuating tumor-resident CD8(+) T cells. Cell Rep Med 2023 Aug 15.
2. Chung CH, Lin CY, Chen CY, Hsueh CW, Chang YW, Wang CC, Chu PY, Tai SK, Yang MH*. Ferroptosis Signature Shapes the Immune Profiles to Enhance the Response to Immune Checkpoint Inhibitors in Head and Neck Cancer. Adv Sci (Weinh). 2023 Apr 7:e2204514.
3. Cheng HY, Hsieh CH, Lin PH, Chen YT, Hsu DS, Tai SK, Chu PY, Yang MH*. Snail-regulated exosomal microRNA-21 suppresses NLRP3 inflammasome activity to enhance cisplatin resistance. J Immunother Cancer. 2022 Aug;10(8):e004832. doi: 10.1136/jitc-2022-004832.
4. Chen CC, Hsu CC, Chen SL, Lin PH, Chen JP, Pan YR, Huang CE, Chen YJ, Chen YY, Wu YY, Yang MH*. RAS Mediates BET Inhibitor-Endued Repression of Lymphoma Migration and Prognosticates a Novel Proteomics-Based Subgroup of DLBCL through Its Negative Regulator IQGAP3. Cancers. 2021 Oct 7;13(19):5024.
5. Ou DL, Chen CW, Hsu CL, Chung CH, Feng ZR, Lee BS, Cheng AL, Yang MH*, Hsu C*. Regorafenib enhances antitumor immunity via inhibition of p38 kinase/Creb1/Klf4 axis in tumor-associated macrophages. J Immunother Cancer. 2021 Mar;9(3):e001657.
6. Liao TT, Lin CC, Jiang JK, Yang SH, Teng HW, Yang MH*. Harnessing stemness and PD-L1 expression by AT-rich interaction domain-containing protein 3B in colorectal cancer. Theranostics. 2020 May 15;10(14):6095-6112.
7. Li CF, Chen JY, Ho YH, Hsu WH, Wu LC, Lan HY, Hsu DS, Tai SK, Chang YC*, Yang MH*. Snail-induced claudin-11 prompts collective migration for tumour progression. Nat Cell Biol. 2019 Feb;21(2):251-262.
8. Pan YR, Chen CC, Chan YT, Wang HJ, Chien FT, Chen YL, Liu JL, Yang MH*. STAT3-coordinated migration facilitates the dissemination of diffuse large B-cell lymphomas. Nat Commun. 2018 Sep 12;9(1):3696.
9. Hsu DS, Hwang WL, Yuh CH, Chu CH, Ho YH, Chen PB, Lin HS, Lin HK, Wu SP, Lin CY, Hsu WH, Lan HY, Wang HJ, Tai SK, Hung MC, Yang MH*. Lymphotoxin-beta interacts with methylated EGFR to mediate acquired resistance to cetuximab in head and neck cancer. Clin Cancer Res. 2017 Aug 1;23(15):4388-4401.
10. Hsu DS, Wang SJ, Tai SK, Chou CH, Hsieh CH, Chiu PH, Chen NJ, Yang MH*. Acetylation of Snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages. Cancer Cell . 2014;26:534-548.
11. Hwang WL, Jiang JK, Yang SH, Huang TS, Lan HY, Teng HW, Yang CY, Tsai YP, Lin CH, Wang HW*, Yang MH*. MicroRNA-146a directs the symmetrical division of Snail-dominant colorectal cancer stem cells. Nat Cell Biol. 2014;16:268-280.